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When the ER:ER ratio was high, NPY transcription was repressed

Other immune modulators, such as Toll-like receptor (TLR) agonists (e.g., vidutolimod, imiquimod, or poly (I:C)) [360, 361] and cytokines such as IL-6 [362, 363], can further reshape the TME to foster a more immunogenic and T-cell-supportive milieu

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Interestingly, compared with sedentary controls, bone marrow-derived macrophages (BMDMs) from exercise-trained mice show reduced LPS-induced NF-B activation and proinflammatory gene expression, along with increased expression of M2-related genes, these changes are associated with improved mitochondrial quality, increased reliance on oxidative phosphorylation, and reduced ROS production (35, 36)

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