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Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation

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Woutersen RA, Appelman LM, Feron VJ, & der Heijden CA (1984) Inhalation toxicity of acetaldehyde in rats

Consequently, the pH of the system is also known to induce changes in enzyme activity

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress