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this, in turn, leads to accentuated elevations in blood concentrations of tHcy and MMA, and exacerbation of neurological sequelae due to vitamin B-12 deficiency in the brain and peripheral nervous system To test these and other predictions, in addition to human studies, it will be important to develop better animal models with closer similarity to the physiologic and clinical features of vitamin B-12 deficiency than rodent models currently provide

A variety of enzymes, including -galactosidase, 734 penicillin G acylase, 735 horseradish peroxidase, 736 cellulases, 737 proteases, 328 phosphotriesterases, 738 and dehydrogenases 739 have been engineered using this method

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Dysregulated ferroptosis mediates pathogenic progression in autoimmune disorders by causing excessive immune cells death or dysfunction

Oxidation of DNA: damage to nucleobases

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