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For example, a small pilot study might suggest benefits, but without larger, randomized controlled trials, these results are not reliable

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Despite the above mechanisms it is also possible that, to some extent, the association between AD and homocysteine simply reflects co-existing vascular disease rather than an association with pure AD pathology

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arXiv:0904.0575

The economist Alex Tabarrok has written that when an approved drug harms people there are front-page stories, but when the FDA fails to approve a good drug
