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For example, heparinase, an enzyme that degrades heparan sulphate and enhances the invasive and metastatic capacity of cancer cells, was reported to be activated by s -cysteinylation

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Therefore, focus has been drawn towards targeting the glutathione antioxidant system in tumor cells as a therapeutic approach using drugs to target glutathione directly, indirectly, or by using glutathione-based prodrugs (Figure 4) [15]

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IFN, a group of signaling proteins produced and secreted by host cells in response to pathogen infection (96, 97), has been used in the treatment of hepatitis B virus infection (98100)

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