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This structural relationship has made Dihexa useful for comparative investigations of angiotensin-derived compounds, structure-activity relationships, peptide-derived signaling modulators, and the molecular determinants governing receptor-associated signaling pathways.

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Additionally, treatment of trophoblast cells with hypoxia reduces cell invasion and induces ferroptosis by downregulating SCL7A11, GPX4 and FPN1 expression (84)

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Woo KT, Choong HL, Wong KS, Tan HB, Chan CM (2012) The contribution of chronic kidney disease to the global burden of major noncommunicable diseases