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research grant 353640 to A.A.S

It also reduces glucose uptake by fat cells, lowering the substrate supply for new fat formation

Risk assessments for human inhalation toxicity based on traditional animal studies generally include a safety factor of 25 to account for uncertainties related to interspecies (animal-to-human: 2.5-safety factor) and inter-individual (human-to-human: 10-safety factor) variabilities ( in vitro PoDs from MucilAir readouts (i.e., TEER, lactate dehydrogenase leakage and resazurin metabolism analyses) with dosimetry information obtained from a computational fluid-particle dynamics (CFPD) model (Ramanarayanan et al., 2022)

Furthermore, only two of the studies assessed in vivo cellular uptake and only two assessed potential biological effects