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reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation
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Additionally, a decreased incidence of diabetes was observed in HCV patients treated with DAAs (Adinolfi et al., 2020)

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