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In view of the protection of VB 12 in CBS deficiency disease [2], we exogenously administered VB 12 into mice to evaluate whether it is beneficial to AP

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This favorable safety profile potentially makes it more suitable for long-term joint support applications compared to systemic growth hormone treatment, though direct comparative studies have not been conducted

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This route bypasses first-pass liver metabolism, theoretically providing higher bioavailability than oral ingestion

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