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Interleukin-12/23 Inhibitors Ustekinumab (UST) is the only anti-interleukin (IL)-12/IL-23 approved for UC at this time, and acts by binding to the p40 subunit of IL-12 and IL-23, preventing the interaction of these cytokines with the IL-12 receptor 1 subunit of the IL-12 and IL-23 receptor complexes, thus affecting lymphocytes' function and downregulating proinflammatory cytokines

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10.1021/jf011480w

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All patients were fully supplemented with folic acid and vitamin B12