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Where racetams modulate acetylcholine receptors and stimulants increase catecholamine release, peptide nootropics directly influence neurotrophic factors, neuroplasticity pathways, and neuroprotective mechanisms that determine the brain's structural and functional capacity

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The mechanosensitive disc cells responded with an up-regulation of different anabolic but also catabolic genes such as aggrecan, TIMP-1, ADAMTS-4, MMP-3 and MMP-13

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