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Utilization of intracellular acetyl-L-carnitine pools by mononuclear phagocytes

L-carnitine accomplishes this by binding to acyl residues produced not only from fatty acids but also from amino acid metabolism, forming water-soluble acylcarnitines that facilitate their excretion from cells and ultimately the body (Figure 1) ( 2.4 Stabilization of cell membranes L-carnitine is also essential in maintaining membrane stability and the function of plasma, mitochondria, and other organelles, probably through its effects on the acetylation of membrane phospholipids

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It is interesting that even though RLS patients sleep less than 5 hours per night, they rarely report problems with excessive daytime sleepiness

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Conversely, unresponsive patients show minimal changes in outcomes, suggesting that factors beyond L- carnitine adequacy may contribute to their unresponsiveness