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Lauroylcarnitine (C12-carnitine) can inhibit AMPK and secrete proinflammatory cytokines to promote the polarization of bone marrow-derived macrophages to the pro-inflammatory M1 phenotype [57]

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The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

Dumas M-E, Maibaum EC, Teague C, Ueshima H, Zhou B, Lindon JC, Nicholson JK, Stamler J, Elliott P, Chan Q, Holmes E (2006) Assessment of analytical reproducibility of 1h nmr spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP study

An important implication of these findings is the need for interventions as early as at first diagnosis of acute infection for LC prevention