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Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
Whereas expression of the enzymatically inactive mutants did not significantly affect the abundancy of cellular ATP comparing to cells transfected with the empty vector, expression of wild-type Ceg14 led to ~90% reduction

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It is typically initiated by the cleavage of GSDMD via inflammatory caspases (caspase-1/4/5/11) or GSDME by apoptotic caspase-3

Cancer Epidemiol Biomarkers Prev 18 (8): 21762181
