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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)

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Cytochrome P-450 omega-hydroxylase: a potential O (2) sensor in rat arterioles and skeletal muscle cells

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Metabolites 12(6):514 Sarkar S et al (2019) Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of nonalcoholic fatty liver disease