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A 2025 Phase I trial (Lee & Burgess, 2025) demonstrated that IV BPC-157 doses up to 20 mg were tolerated in healthy volunteers with no serious adverse events

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doi: 10.1016/j.cpcardiol.2018.06.005 2 al-WaizM.MikovM.MitchellSCSmithR

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In melanin-rich skin, there is more pigment in the epidermis, which means the laser energy can be absorbed earlier than intended. Jeanine Downie, MD, a board-certified dermatologist in Montclair, New Jersey, says melanin-rich skin has melanocytes that are larger and generally have higher baseline activity levels. She adds that these pigment-producing cells release more inflammatory 'mediators' faster than in those [in lighter skin tones] in response to heat or other trauma. Signs of a poor reaction to laser hair removal would be pretty immediate during treatment