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Common ingredients in pre-workouts include: L-Citrulline Small studies using lower doses of L-citrulline malate have shown some improvements in cycling performance and muscle soreness, though some larger-scale meta-analyses of aerobic performance have revealed mixed results, even with higher doses.35 36 Other large reviews have been more positive, especially at 8g/day and above.45 The trend in the literature seems to indicate that higher doses would be more effective, though many pre-workout supplements offer 6g or less

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In the context of FM, SAMe has been studied for its potential therapeutic benefits in alleviating symptoms

Caffeine not only counteracts the metabolism- slowing effects of adenosine an organic compound that naturally builds up in your body to create feelings of tiredness but it also makes your cells more sensitive to hormones such as adrenalin