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doi: 10.1038/nature12503 90

The ATM specific kinase inhibitor KU60019 (Tocris, UK) was dissolved in DMSO to 100 mM then diluted to 5 M directly into media

To rank the potential drug targets identified, we prioritised enzymes for unique reactions that occur at the nodes of intersection between the bottleneck and essential reactions and the results from the human/virus proteinprotein interaction network (Gordon et al, 2020) (Table 1)

Metabolic orchestration driven by GGCT: diverting glutamine to glutathione biosynthesis while enhancing glucose anaplerosis for tumor proliferation

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