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Hvas and Nexo (2005) proposed holotranscobalamin as a first-choice assay for diagnosing early vitamin B12 deficiency, interpreted within the broader clinical context rather than in isolation (11,13)

MELATONIN SYNTHESIS AND METABOLISM Melatonin Synthesis Melatonin (N-acetyl-5-methoxytryptamine) is synthesized within the pinealocytes from tryptophan, mostly occurring during the dark phase of the day, when there is a major increase in the activity of serotonin-N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT), responsible for the transformation of 5-hydroxytryptamine (5HT, serotonin) to N-acetylserotonin (NAS) (Figure 1)

K., Zareef, R

Baranano DE, Rao M, Ferris CD, Snyder SH

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Marshell, R