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Preclinical Characterization of SAR650984, a Humanized Anti-CD38 Antibody for the Treatment of Multiple Myeloma: P-288

In senescent cells, NF-B is often constitutively activated, driving chronic inflammation.131 Senomorphic agents can inhibit this pathway, reducing the secretion of inflammatory cytokines and alleviating the deleterious effects of chronic inflammation.132 JAK/STAT Pathway: The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in the inflammatory signaling of senescent cells

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Additionally, neomycin was tested in ME/CFS patients with small intestinal bacterial overgrowth, resulting in reported improvements in pain, depression, and cognitive function [177]

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