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Frank Gwilliam introduced generations of Reed students to the discipline of biology

Trends in biochemical sciences

In contrast to previous studies reporting NCOA4 383522 can dimerize despite lacking the N-terminal coiled-coil oligomerization domain contained in the full-length protein (Gryzik et al, 2017), we found that NCOA4 383522 was monomeric at our working concentrations, as assessed by SEC-MALS (Fig S1C)

19,84 Hepatocyte-specific SIRT1 knockout mice display liver steatosis, triglyceride accumulation, and increased de novo lipogenesis, even under standard dietary conditions, accompanied by SREBP-1c activation and impaired PGC-1/peroxisome proliferator-activated receptor alpha (PPAR) signaling

However, as there is an increased incidence of pneumonia, asthma, and COPD in diabetes [12], this study reaffirms the beneficial effect of GLP-1 receptor agonists in reducing the number of these diseases

Liu, W., Yang, X., Zhou, Z
