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Collectively, these findings suggest that the antioxidant NAC treatment successfully rescued the exacerbated ROS generation, SGNs loss, and apoptosis caused by GPX1-deficiency after peroxynitrite damage

Dialysis may be required temporarily (renal recovery generally occurs eventually if the patient survives)

After exocytosis, membrane PAM appears on the plasma membrane, where it is rapidly internalized and is either packaged into secretory granules or undergoes degradation (Milgram et al., 1994

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The GCLC-KO mouse brain displays severe neuroinflammation at an early stage of brain atrophy Numerous studies have noted the importance of neuroinflammation in neurodegenerative processes 20

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