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Despite recent advancements in early diagnosis and personalized treatments, cancer incidence is increasing steadily, and the overall survival rate of patients remains poor (Balani et al., 2017)

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Copper induces oxidative stress and H 2 O 2 production in HepG2 ATP7B-KO cells After 6 h of CuCl treatment, chosen oxidative stress-related genes were significantly upregulated in HepG2 ATP7B-KO cells, while only HMOX1 showed early induction in HepG2 cells