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The central processing unit is located primarily in the hypothalamus, especially in the arcuate nucleus, which integrates the afferent signals from leptin, insulin, and ghrelin

67 RaiA.TripathiP.DwivediS.DubeyS.ShriM.KumarS.et al (2011)

Shaking can denature or degrade the peptide

GABA in the paraventricular nucleus tonically suppresses baroreflex function: alterations during pregnancy

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They also generate reactive oxygen species during normal metabolism
