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GHK-Cu also modulates the activity of growth factors such as TGF- and VEGF, which are critical for tissue repair

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These include increases in metabolic activity in the dorsomedial PFC and insula, but decreases in activity within a region encompassing the nucleus of the solitary tract and brainstem 5-HT neurons [141], all regions implicated in the networks of depression [132]

They are discussed for overlapping reasons, but they come from different biological concepts, are studied through different mechanisms, and raise different safety and regulatory questions