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Special population studies, including evaluation in elderly patients, patients with significant comorbidities, and patients with organ dysfunction, would help establish safety profiles for diverse clinical populations

Muscle cramps are common in adults and become increasingly frequent with aging

Sodium Hydroxymethylglycinate

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism

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Research conducted in one population may not apply to different cultural contexts, limiting the generalizability of current findings