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148.Recondo G, Bahcall M, Spurr LF, Che J, Ricciuti B, Leonardi GC, Lo Y-C, Li YY, Lamberti G, Nguyen T, et al

Gently roll the vial between your palms if needed

Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)

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Delivery method (injection typically outperforms topical)

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