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Nagao A, Kobayashi M, Koyasu S, Chow CCT, Harada H

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Here we review the current understanding of the role of DiY on A and tau gathered over the last 20 years since the first observation, and discuss the effect of this modification for A and tau aggregation, and its potential as a biomarker for AD

These include its transport into specific cells and its particular neuroprotective actionof which an antioxidant effect in dysfunctional neurons and an anti-inflammatory effect have strong supportive evidence from experimental studies, as discussed below

Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties