intracellular glutathione pool Dynamics in Subcellular Compartments and Implications for Drug Development Use with Flow cytometer. Mitochondrial Glutathione in Cellular Redox

We show (i) that PfGrx-catalyzed redox reactions outcompete uncatalyzed reactions between roGFP2 and GSH or GSSG by several orders of magnitude, (ii) that the PfGrx-catalyzed reduction and oxidation of roGFP2 occur via a mono- and not a dithiol mechanism, and (iii) that the reduction of roGFP2(S 2 ) as a model non-glutathione disulfide substrate most likely involves a rate-limiting glutathionylation in a ternary complex with a GSH molecule that is activated at the 1st glutathione-interaction site of PfGrx

(2227-9059 (Print))

The main mechanism of vitamin involvement in these processes is throughout their modulation of oxidative stress and interactions with antioxidant enzymes and vitagenes (i.e., genes that maintain cellular homeostasis during stressful conditions)

CYBB, Cytochrome B-245 Beta chain

Liu, H., Colavitti, R., Rovira, I

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