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DNA adducts are formed through binding of compounds such as acetaldehyde and modified bases, which are known for their ability to induce mutations in the DNA that facilitates activation of oncogenes, through inactivation of tumor suppressor genes, and through immune response due to recognition of proteins bound to foreign structures by the immune system

2017;21(6):671-681.e4

Early chemotherapy is chiefly focused on the direct targeting of the DNA strand, with platinum compounds, comedones, vincristine, paclitaxel, and anthracyclines being the most commonly used [195,196,197,198,199]

doi:10.3389/fonc.2014.00283 [DOI] [PMC free article] [PubMed] [Google Scholar] 49.Yeom CH, Jung GC, Song KJ

World J Gastroenterol 6(4):483489 Lautenschlager C, Schmidt C, Fischer D, Stallmach A (2014) Drug delivery strategies in the therapy of inflammatory bowel disease

Volta U, Caio G, Tovoli F, De Giorgio R