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By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism

Glucose Signaling and Endocrine Pathways AOD 9604 has been investigated in laboratory models assessing glucose metabolism and endocrine signaling

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Moreover, RS004 (Sen et al., 2019) were also reported to compete with NAM for binding by covalently linking to Cys165 and Cys159 in the active site of NNMT