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The high reactivity of HNE results from the diminished electron density around carbon-3 of HNE as a consequence of two factors: 1 ) the resonance between the C=C of carbons-2 and -3 and the C=O bond of the aldehyde functional group on carbon-1 and 2 ) the inductive effect of the more electronegative O atom on the OH group of carbon-4 with the electrons around carbon-3
PMID: 7453802
Consistent with a neuroprotective function of TFG, its CRISPRi-mediated depletion in induced pluripotent stem cell (iPSC)-derived neurons led to increased damage upon LLOMe treatment, as assessed by higher numbers of mCherryGal3 puncta compared with control neurons (Extended Data Fig
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Mechanism of glucose-6-phosphate dehydrogenase-mediated regulation of coronary artery contractility
doi: 10.3760/cma.j.cn121430-20220809-00731 107 WuTJWangSHChenESTsaiHHChangYCTsengYHet al
