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In HD models, increased mitochondrial fragmentation and impaired clearance have been reported, supporting the possibility of mtDNA leakage as a neuroinflammatory trigger [186]

The intricate balance of water in our systems is essential for maintaining homeostasis, and any disruption to this balance can have cascading effects on our overall health

Depending on the signals received in the plaque microenvironment, recruited monocytes can assume variety of macrophage identities including inflammatory macrophages, aortic intima-resident macrophages (Mac AIR ), and type I interferon-inducible cells

PROTAC degraders offer several advantages over traditional small molecule inhibitors, including its intrinsic event-driven pharmacology and nonlinear pharmacodynamics, improved safety profiles, and reduced risk of drug resistance

91 Mindfulness, meditation, and relaxation techniques are recommended to manage stress levels

[DOI] [PubMed] [Google Scholar] 9.Gloviczki P, Comerota AJ, Dalsing MC, et al