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136139 Consistent with these characteristics causing kidney damage through hypoxia, the db/db mouse shows increased glomerular expression of hypoxia-inducible factor 1 (HIF-1) and other genes involved in oxidative stress

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360 Since transcriptional induction of 2-integrin gene expression plays a vital role in macrophage function, work was undertaken to identify the causative molecular mechanisms

In turn, the production of superoxide, hydrogen peroxide, and hydroxyl radicals leads to oxidative stress, causing oxidative damage [54]

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