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The multifactorial nature of DED encompasses a number of interconnected underlying pathologies, including loss of homeostasis, instability and hyperosmolarity of the tears, and the induction and propagation of detrimental inflammatory responses in the eyes, which finally results in the development of neurosensory dysfunction and visual disruption

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Nrf2 is a transcriptional target of PGC1 and Nrf2 which promotes mitochondrial biogenesis [45]

10.1002/humu.21126 Jaeken J, Carchon H: Congenital disorders of glycosylation: a booming chapter of pediatrics

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