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Moreover, rodents such as mice and rats, mostly used in preclinical studies, possess respiratory structures and disease condition models that differ from those of humans, resulting in discrepancies in in vivo drug distribution and pharmacological responses

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Consistent with previous reports that gp91 phox localizes in the membrane as a glycosylated protein (57, 58), gp91 phox was detected in the membrane fraction in both WT and Gsr / neutrophils