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Keywords: lynch syndrome, lynch-like syndrome, hereditary cancer, colorectal cancer, DNA mismatch repair genes 1

One mouse was euthanized on day 12 in MK-801 group due to sickness

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The low abundance hexa- and decadepsipeptide esters are proposed to be generated by an incorrect transfer of D- O -Leu-D-Ala- S -PCP ( DP2a ) onto L- O -Val-L-Val-D- O -Leu-D-Ala- O -TE ( DP4 ) and (L- O -Val-L-Val-D- O -Leu-D-Ala) 2 - O -TE ( DP8 ) leading to the generation of the hexadepsipeptide O -Leu-D-Ala-(L- O -Val-L-Val-D- O -Leu-D-Ala)- O -TE ( DP6a ) and O -Leu-D-Ala-(L- O -Val-L-Val-D- O -Leu-D-Ala) 2 - O -TE ( DP10a ), respectively (Fig

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