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Nat Immunol (2015) 16(4):34353.10.1038/ni.3123 11 PachecoARBarileDUnderwoodMAMillsDA

24 Department of Surgery, McGill University, Montreal, QC, Canada

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Increased Receptor Affinity (Hypothesized): Some research suggests that the lack of the N-terminal tripeptide actually enhances its binding affinity to the IGF-1R in damaged or targeted cells, leading to a strong, immediate growth signal that promotes satellite cell recruitment, repair, and growth

Preclinical research provides a foundational understanding of the biological pathways that SFN influences, which in turn helps shape clinical trials and therapeutic strategies

However, caution should be exercised when using CBD concurrently with drugs that influence cardiac repolarization or impair drug metabolism, as well as in certain pathophysiological situations, such as hypokalemia, channelopathies, diabetes mellitus, hypertrophic myocardiopathy, or heart failure, among others, CBD can have an additive effect, further increasing the proarrhythmic risk and the possible incidence of sudden cardiac death (Figure 5)