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Arctigenin activates the Tolllike receptor signaling pathway in macrophages, enhancing their phagocytic and cytotoxic capabilities [221]

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Wistar rats (55/sex per dose) were exposed for life (6 h/day, 5 days/week, for 28 months) to acetaldehyde concentrations of 1350, 2700, or 1800-5400 mg/m 3 (the last concentration was gradually reduced from 5400 mg/m 3 in week 20 to 1800 mg/m 3 in week 52)

P.Jr.LeutzingerY.ParthasarathyS.MaixoyV.OrentreichN.ZimmermanJ

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Wilce MC, Parker MW: Structure and function of glutathione S-transferases