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While the clinical significance remains unclear, women relying on oral contraceptives should be advised about potential interactions and may need to consider additional contraceptive methods or more frequent monitoring to ensure continued effectiveness

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For detecting metabolic proteins and cytokines, cells were fixed and permeabilized using Cytofix/Cytoperm (BD) for 20 min at 4 C, followed by intracellular staining with all other metabolic proteins, IFN-BUV737 (BD 612845) and IL-17A-BV786 (Biolegend 512338) in 1X permeabilization buffer (eBioscience) for 40 min in the dark at 4 C

Ye et al., 2019)

Historical review of Peyronies disease: de la Peyronie to Devine