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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

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(8.1) Females of Reproductive Potential: Advise females using oral contraceptives to switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation

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26,110,111 It has been suggested that the injury mainly involves death-receptor-mediated apoptosis, followed by innate and adaptive immune responses

Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations
