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Plan of analysis All analyses will initially be done on an intent-to-treat basis

Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS)

However, Epitalon may support several mechanisms associated with healthier aging, including: Telomere maintenance DNA protection Sleep optimization Oxidative stress reduction Cellular renewal pathways Researchers continue to investigate whether these effects can meaningfully influence biological aging

10.1016/j.nutres.2015.11.019 139

By targeting the PI3K/AKT and p53 pathways, metformin could also enhance NK cell cytotoxicity and may be used as an immunopotentiator for combination therapy with immunotherapy (Xia et al., 2020)

Luo D, Geng J, Li N, Carter KA, Shao S, Atilla-Gokcumen GE, et al