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doi: 10.1016/j.lwt.2020.110300 174

Chin J Cancer Res

5.3 Distinct mechanisms of adipocyte elimination in metabolic disease AT undergoes several forms of cellular elimination under metabolic stress: mitochondrial-dependent apoptotic pathways, inflammatory cell death via receptor-interacting serine/threonine-protein kinase 3 (RIPK3)/Mixed lineage kinase domain-like protein (MLKL) signaling, and inflammasome-triggered membrane disruption through specific molecular cascades (392)

The Ontario Graduate Scholarship Program Award (C.E.P.)

Results Influence of A pathology on ferroptosis-related protein levels To investigate the link between A pathology and ferroptosis-related proteins in post-mortem AD brain tissue, we selected mature A plaques in patients from several AD groups (termed AD1, AD2 and AD3 based on the pathology status, as described in Material and Methods section) and compared the expression of ferroptosis-related proteins in the A plaque area with the adjacent area without any plaques (Fig