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Clinical protocols must include stringent monitoring

Research shows increased GLUT4 expression leading to better glucose clearance, enhanced insulin receptor sensitivity, and normalized metabolic parameters

It is also needed for healthy red blood cell formation and for the development and function of the central nervous system (brain, spinal cord, and nerves)

Storage After Reconstitution: Once reconstituted with sterile water or appropriate diluent, store the solution at 28C (refrigerated)

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Most of the product licences, or marketing authorities as they are called in the UK, for hydroxocobalamin date from the 1990s when the requirement for evidence was different than it is now