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You've gone gluten-free

Under stress conditions, these receptors localize to the mitochondria and promote mitophagy through direct interaction with processed microtubule-associated protein 1 light chain 3 (LC3) via their conserved LC3 interaction regions (LIR) domain

That multi-target approach is precisely what makes them interesting to researchers studying mood disorders, and it is also what makes the topic so difficult to navigate without a comprehensive guide

1993;53(18):PL2916

The polyphenolic compound (-)-gossypol, which is also known as AT101, was shown to promote the expression of BNIP3 and NIX and upregulated heme oxygenase-1 (HMOX1), thus triggering lethal mitophagy and contributing to AT101-induced ACD [15]

Kadayifci, F