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TMZ shows a tolerable toxicity level, with a 7% of grade III-IV hematological toxicity with concomitant radiation, and 14% when administered as an adjuvant [201]

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The tissues were then sliced into 70-nm sections using a Leica-EM-UC6-Microsystem, stained with lead citrate and uranyl acetate, and examined using a Philips-CM-120-TEM to visualize mitochondria