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Researchers have proposed several mechanisms, including direct effects on gene transcription factors and indirect influences through cellular signaling cascades that regulate telomerase activity

197 In terms of cognitive activity, a study of more than 7,000 individuals found that those who had cognitively stimulating occupations in their 30s, 40s, 50s and 60s had a lower risk of MCI and dementia when they were 70 or older

Evidence for an amacrine cell system in the ganglion cell layer of the rat retina

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

In the early stages of HD, hyperkinetic movements are caused by heightened thalamocortical glutamatergic signaling driven by the loss of neurons in the indirect pathway

Mitochondrial dysfunction that occurs in T2DM is inseparable from the glycolytic pathway, presumably it involves increased ROS production and energy expenditure (Qi et al., 2017)