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Description
The combination therapy also showed concomitant protection against cardiovascular complications [47]

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RAGE: receptor for advanced glycation end products

Generally, PD shows major pathology through dopaminergic neuron degeneration in the substantia nigra, causing an approximately 80% decline of dopamine levels in the striatum ( Glutamate represents the dominant excitatory neurotransmitter across central nervous system pathways

First, it helps to prevent oxidation of Vitamin C and Glutathione

Studies have shown that hypotonic formulations improve drug permeability through the nasal mucosa [57]
