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This effect on heart rate is an important safety issue that needs special attention in future trials since obese individuals are at increased cardiovascular risk

These medications work through different receptor mechanisms, have different pharmacokinetic profiles, and produce different physiological responses at every dose level

As Li + is a substrate inhibitor of Na + -dependent neurotransmitter transporters [12, 13] and exchangers [for review see 14] the substitution of Li + for Na + in the external solution decreases the efficacy of Ca 2+ extrusion via NCX

7.2.2 Evaluation of glomerular function Evaluation of blood urea nitrogen is probably the most common procedure for indirectly evaluating GFR in experimental animals

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