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To summarise, we have shown that the interactions of the centrosomal protein CEP192 with Aurora-A compete with spindle microtubule-associated TACC3 and TPX2 binding, and validated the crystal structure using site-specific mutagenesis

PrfA mediates specific binding of RNA polymerase of Listeria monocytogenes to PrfA-dependent virulence gene promoters resulting in a transcriptionally active complex

References Droracle.ai

NCT05394519 ClinicalTrials.gov

While it might be expected that effect sizes in more realistic conditions will be smaller, this is by no means always the case (Mitchell, Reference Mitchell2012) and it may even be that enhanced realism of presented scenarios facilitates the release of more pronounced effects

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